AZ: FDA autoriza Imfinzi para "endometrial cancer"

 

AstraZeneca’s (AZ) Imfinzi (durvalumab) has been approved by the US Food and Drug Administration (FDA) as part of a combination therapy for a subset of endometrial cancer patients.

Imfinzi plus carboplatin and paclitaxel, followed by Imfinzi monotherapy, is now authorised to treat adults with primary advanced or recurrent endometrial cancer that is mismatch repair deficient (dMMR).

The FDA’s decision was supported by positive results from the late-stage DUO-E trial, in which the Imfinzi regimen reduced the risk of disease progression or death by 58% in patients with dMMR endometrial cancer versus chemotherapy alone.

The safety and tolerability profile of the regimen was generally manageable, well tolerated and broadly consistent with prior clinical trials, AZ said.

Endometrial cancer is the sixth most common cancer in women globally and dMMR disease accounts for up to 30% of all cases.

Patients diagnosed at an early stage of disease have a five-year survival rate of up to 90%, but AZ outlined that there remains a “significant need” for new treatment options for those with advanced disease, where the survival rate falls to less than 20%.

Imfinzi, which already holds approvals in lung cancer, biliary tract cancer and hepatocellular carcinoma, is a human monoclonal antibody designed to block the interaction of PD-L1 with the PD-1 and CD80 proteins, countering the tumour’s immune-evading tactics and releasing the inhibition of immune responses.

Commenting on the latest authorisation for the drug, Dave Fredrickson, executive vice president, oncology business unit, AZ, said: “There have been limited advances in the treatment of endometrial cancer in the last few decades, and continued innovation is critical as the burden of this cancer is expected to grow in the future.

“Immunotherapy in combination with chemotherapy is emerging as a new standard of care in this setting and the approval of Imfinzi offers an important new option for patients with dMMR disease.”

DUO-E has also been evaluating Imfinzi plus chemotherapy, followed by Imfinzi plus Lynparza (olaparib), as a maintenance therapy. Regulatory applications for both Imfinzi and Imfinzi/Lynparza regimens are currently under review in the EU and several other countries based on results from the study.

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Big Pharma paga "influencers"...

 

Physician influencers are getting paid quite well by Big Pharma companies for their social media posts.

More than 90% of physicians who posted an endorsement of a drug or medical device on X, the social media platform formerly known as Twitter, received payments from pharma companies, according to a recent analysis published in JAMA.

The study found that industry payments to doctors totaled up to $2.46 billion in 2022.

Among the 28 doctors included in the study, 26 of them received payments from pharma companies for a variety of reasons — most often marked as food and beverages, speaking or consulting fees.

The average payment to doctors from drugmakers was around $27,400.

However, most of Big Pharma’s payments to doctors went toward “speaking,” with some $377,000 paid to 18 physicians for speaking activities.

The researchers also pinpointed 24 times in which physicians received payments that were linked to them mentioning a specific drug or medical device on X.

Half of the doctors who endorsed drugs on X had no research publications related to the products and almost half of the physicians did not disclose that they were being paid by the drugmakers.

The companies that paid physicians surveyed in the study included Pfizer, GSK, Eisai, AstraZeneca, Novartis, Exelixis and Boston Scientific.

The results of the study bring up questions about the validity of physician endorsements on social media — especially if the doctors in question don’t disclose the compensation they receive from companies, the authors argued.

“[T]he conflict of interest… may not be apparent to the general social media audience,” the authors wrote.

“These payments can represent scientific collaboration but may involve marketing efforts without scientific benefits, raising concerns regarding their influence on clinical decision-making,” they continued. “[P]articipation in industry marketing raises questions regarding professionalism and their responsibilities as patient advocates.”

The role of physicians in marketing a drugmaker’s product for compensation has been a long debated topic, even drawing scrutiny in Congress over the past decade.

In 2014, lawmakers included a rule in the Affordable Care Act which required pharma companies to report their payments to physicians.

Under that bill, the Centers for Medicare and Medicaid Services launched the Open Payments database, which tracks the financial relationships between doctors and drugmakers and makes payments more transparent.

Still, research suggests that the launch of Open Payments hasn’t deterred physicians from accepting Big Pharma payments too much.

One 2020 study found that 45% of doctors accepted at least one payment from industry in 2018, compared to 52% of doctors in 2014.

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España: KOL "bien pagados..."

Los profesionales sanitarios líderes de opinión recibieron 103 millones de euros de 18 farmacéuticas en concepto de actividades formativas, reuniones científico-profesionales, asistencia a congresos o prestación de servicios. 25 millones se repartieron solo entre 855 profesionales sanitarios. Es lo que se conoce como ‘transferencia de valor‘, que desde 2016 las compañías farmacéuticas adheridas al Código de Buenas Prácticas de Farmaindustria hacen públicas.

Así se desprende de un extenso estudio publicado por la Asociación Acceso Justo al Medicamento (AAJM) y realizado por el inspector Farmacéutico del Servicio de Salud de Castilla-La Mancha (Sescam) y vicepresidente de la AAJM, Ángel Mª Martín Fernández-Gallardo. Según el texto, 855 profesionales sanitarios españoles recibieron más de 15.000 euros anuales de las 18 principales multinacionales farmacéuticas por volumen de ventas en varios pagos a lo largo de 2022 (un solo profesional llegó a facturar hasta 146.397 euros y solo 14 recibieron pagos de una sola multinacional). Son datos, según se desprende del artículo consultado por THE OBJECTIVE, obtenidos de los informes de transparencia de estos laboratorios.

Janssen, la farmacéutica que paga a más líderes de opinión 

Por farmacéuticas, Janssen es la que más ha pagado a estos profesionales españoles en concepto de actividades formativas, reuniones científico-profesionales o asistencia a congresos. De los datos del estudio de la Asociación Acceso Justo al Medicamento (AAJM) se desprende que pagó más de 5.000 euros a 528 líderes de opinión, con una inversión total de cinco millones. De esta forma, la compañía belga queda lejos del segundo laboratorio que más invierte en transferencia de valor, GSK, que repartió casi tres millones (2.959.162) en 274 profesionales médicos durante 2022.

En tercera posición aparece Pfizer, con pagos de más de 5.000 euros a 241 líderes de opinión por un importe total de 2.680.722 millones; AstraZeneca se encuentra en cuarta posición, con 226 profesionales médicos y casi dos millones y medios en concepto de transferencias de valor. La quinta posición la ocupa Sanofi (225 profesionales y 2.144.660 euros). El ranking de los diez laboratorios que más destinan a profesionales españoles para estas actividades lo completa Abvie (214 profesionales y 2.029.854 euros), Gilead (167 profesionales y 1.178.639), Lilly (163 profesionales y 1.631.800 euros), MSD (125 profesionales y 1.214.253 euros) y Merck (101 profesionales y 1.074.572 euros).

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«Llevo Janssen y AstraZeneca» / Kiko Miyares

"Hay un motorista con casco amarillo y llamas a sus espaldas. Es una anamorfosis (una deformación) de madera con forma de escultura –de Kiko Miyares–. Se llama «Llevo Janssen y AstraZeneca», es decir, llevo dos de las vacunas que estuvieron tan de moda cuando la pandemia detuvo el mundo."

Saúl Fernandez LNE 13.4.2024

What did Big Pharma CEOs get paid in 2023? : AZ...(I)

 

It’s that time of year again when Big Pharma companies publicly release the total compensation for their CEOs and top executives from the year before.

Over the coming weeks, publicly-traded pharma and biotech companies will outline how much their leadership teams received in base pay and salaries during 2023.

The issue of executive pay is one that is closely watched — and occasionally criticized — across the industry in light of debates surrounding income inequality and the ratio of CEO salaries to that of median employees.

Check out the list below of total executive compensation for pharma companies, which will be updated throughout the spring.

AstraZeneca

AstraZeneca CEO Pascal Soriot received a total compensation package of £16.9 million in 2023, up from £15.3 million in 2022.

In the company’s annual report issued earlier this week, the British pharma giant indicated that Soriot is eligible to receive up to £18.6 million this year depending on the company’s financial performance.

During its most recent quarter, the drugmaker recorded total revenue of just over $12 billion, with its reported earnings per share (EPS) rising 5% at constant exchange rates (CER) to $0.62, while its core EPS increased 7% to $1.45.

For the full year, AstraZeneca’s total revenues rose 6% to $45.8 billion, supported by 4% product sales revenue growth. The company’s reported EPS increased 96% year-over-year to $3.84 and its core EPS rose 15% to $7.26.

However, that wasn’t enough to impress Wall Street analysts, as the quarterly core EPS was below analyst expectations of $1.48 and the revenue figure barely exceeded expectations of $12.01 billion.

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MRS Monitor de Reputación sanitaria (I) Empresas farmacéuticas con mejor reputación

 

MRS es el único estudio independiente que analiza la reputación de toda la sanidad española y cuenta con el aval de organizaciones y asociaciones del sector

El Monitor de Reputación Sanitaria (MRS) 2023  presenta la primera parte de su novena edición, en la que da a conocer las empresas farmacéuticas con mejor reputación a nivel global, así como las más reputadas e innovadoras por área terapéutica.

Este es el único estudio independiente que analiza la reputación de toda la sanidad española y que cuenta con el aval de las organizaciones colegiales de médicos y enfermeros, así como de las asociaciones de pacientes y periodistas sanitarios.

Más 

Ver: Todo sobre MRS en PHARMACOSERÍAS

TEZSPIRES´s latest TV spot

 

With the success of the Be You campaign last year, Amgen and AstraZeneca decided to build on its existing cast of characters with a deeper dive into the back story of punk rocker Hawk.

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Tezspire, the treatment for severe asthma from Amgen and AstraZeneca, is back with an updated commercial for its ongoing Be You campaign.

Some readers may recall that last year, this column covered the launch of Be You, the first direct to consumer campaign for Tezspire. The effort was built around a number of different asthma sufferers, all represented by animated characters.

The cast included Geraldine, a grandmother with a passion for hot rods; Mel, a mother with asthma seen chopping wood; Kai, a Samoan ice sculptor for whom cold air is a trigger; and Hawk, a punk rocker with a fondness for kittens. 

 

In the updated commercial push, the last character on that list has become the star of the show. This follows a time-tested marketing strategy: If it ain’t broke, don’t fix it.

With the success of Be You last year, Amgen and AstraZeneca decided to build on its existing cast of characters with a deeper dive into the back story of Hawk. 

 

Flashing back to the start of his music career, Hawk is seen rehearsing in a garage (with an asthma-triggering cat present, too). Ultimately, he’s able to address his asthma symptoms by using Tezspire. 

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Tezspire "respira" con punk rocker Hawk...

 

With the success of the Be You campaign last year, Amgen and AstraZeneca decided to build on its existing cast of characters with a deeper dive into the back story of punk rocker Hawk.

 Some readers may recall that last year, this column covered the launch of Be You, the first direct to consumer campaign for Tezspire. The effort was built around a number of different asthma sufferers, all represented by animated characters.

The cast included Geraldine, a grandmother with a passion for hot rods; Mel, a mother with asthma seen chopping wood; Kai, a Samoan ice sculptor for whom cold air is a trigger; and Hawk, a punk rocker with a fondness for kittens. 

 

In the updated commercial push, the last character on that list has become the star of the show. This follows a time-tested marketing strategy: If it ain’t broke, don’t fix it.

Flashing back to the start of his music career, Hawk is seen rehearsing in a garage (with an asthma-triggering cat present, too). Ultimately, he’s able to address his asthma symptoms by using Tezspire.

 Más

Top most valuable Pharma Brands 2023

 

 

The impact of COVID, flu, and RSV on U.S. and U.K. hospitals is expected to be lower this winter compared to last, as there won't be a significant overlap between peak outbreaks of infections, the London-based data analytics firm Airfinity said in a recent report.

However, with COVID in the mix, the hospital burden is likely to be 3.4 times and 2.6 times higher this season compared to pre-pandemic days in the U.S. and the U.K., respectively.

Airfinity projects hospitalizations linked to the three viruses to peak at 57K weekly admissions at the end of January in the U.S., down from 80K during the last winter.

The COVID wave in the nation is expected to peak in November before flu and RSV spikes early next year, as indicated in the graph below.

Just last week, the CDC warned about a potential "tripledemic" caused by the three respiratory pathogens against which FDA-approved vaccines will be available for the first time this year.

The season's peak outbreaks of COVID, RSV, and flu infections are expected to stretch between September and April, a prolonged duration compared to the rapid but sharp spikes in October and February during the 2022–23 season.

"Uptake of COVID and flu boosters as well as the rollout of the new vaccines to protect older people against RSV, could help reduce this burden further this year," 

Dr. Louise Blair, Airfinity's Senior Director of Analysis and Insights, remarked.

Last week, the CDC endorsed updated COVID-19 boosters from Pfizer /BioNTech  and Moderna. Novavax's updated COVID shot is currently under FDA review.

A few months ago, Pfizer  and GSK  won the CDC nod to roll out their vaccines branded as Abrysvo and Arexvy to prevent RSV infections in people aged 60 years and older.

CSL Limited, GSK , Sanofi  , and AstraZeneca are authorized to market their flu vaccine for the 2023–24 influenza season.

Meanwhile, in the U.K., where a new wave of COVID infections has started, peak weekly hospitalizations are expected to reach 13.5K by late September. Shortly thereafter, flu and RSV waves are set to peak in February and November, respectively, leading to a second peak in hospital admissions.

"We expect this year's peaks to be more in line with historical averages as population immunity is higher and fewer people will be susceptible to severe disease," Airfinity's Dr. Blair added.

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Pharma necesita crecer...y busca como

 

 

 

 

Evitar caida de ventas por pérdida de patentes...

 

 

PHARMA: Loock & feel de marca en RR.SS

 

Actualmente, la comunicación y las redes sociales se han convertido en recursos imprescindibles para las compañías y a su vez, para el sector salud y la industria farmacéutica. En concreto, los laboratorios las usan no solo para generar confianza y establecer relaciones sólidas con todos sus stakeholders, sino para recopilar información sobre las preferencias, necesidades y opiniones de los pacientes, entre otros.

En el caso de los pacientes, el foco de estas plataformas está puesto en el disease awareness, o sea, en educar y concienciar sobre temas de salud, ya sea mediante conversaciones o contenido multimedia. Además, gracias a la innovación, algunas de las RRSS disponibles también permiten tener un acceso directo y rápido a los profesionales médicos, con los que se posibilita el intercambio de información y conocimiento a nivel profesional.

En este sentido, desde Elogia Pharma han elaborado recientemente la primera edición de esta Radiografía de Salud de Marca en RRSS de Laboratorios Farmacéuticos, con el objetivo de entender el uso que la industria farmacéutica está haciendo de las RRSS. Y bien, entre algunas de las principales conclusiones destaca que, a la hora de elegir entre una estrategia local o global, un 76% opta por una estrategia mixta, combinando perfiles locales con internacionales.

Linkedin y Twitter, las RRSS más profesionales

En este contexto, LinkedIn es la red social por la que la mayoría de los laboratorios apuestan por una estrategia global, ya que un 60% de ellos utiliza en España el perfil internacional en esta red social, mientras que Twitter es la red social más “local”, ya que el 96% de los laboratorios prefiere tener un perfil estrictamente español en esta red social.

Además, según destaca el análisis, LinkedIn y Twitter se usan principalmente en un contexto profesional, para entablar conversaciones con profesionales del sector. 

Estas RRSS ofrecen un espacio para compartir conocimiento, experiencias y perspectivas, facilitando así la interacción y el intercambio de información y proporcionando un ambiente de networking y colaboración. Sin embargo, a su vez, Twitter es la red social con menor interacción y engagement, es la que requiere un esfuerzo editorial mayor, debido a la dinámica de la propia plataforma, ya que en ella se encuentra un flujo de información constante y los tweets tienen un tiempo de vida corto.

Mientras que, Facebook e Instagram son las RRSS mayormente utilizadas para relacionarse con los pacientes y cuidadores, debido al amplio alcance que ofrecen con este tipo de audiencia. Estas plataformas facilitan la cercanía, la creación de comunidades de apoyo, el enfoque en contenido visual, la interacción directa o la realización de awareness disease, entre otros. Además, ofrecen la capacidad de generar engagement con la marca por su labor de investigación en el ámbito de la salud.

Los laboratorios que mejor trabajan el Look & feel de marca 

Ahora bien, el aspecto visual de una marca puede jugar un papel fundamental cuando se trata de recuerdo de marca. Por tanto, mantener la congruencia visual es clave para que los usuarios conecten con nuestra marca y puedan identificar rápidamente de cuál se trata. En este punto del estudio Elogia Pharma llevó a cabo un análisis donde analizaron la congruencia visual, la adaptabilidad a múltiples plataformas y el branding de diferentes compañías concluyendo que, Abbvie, Astrazeneca y Boehringer Ingelheim son las que mejor trabajan este aspecto.

Y es que, según afirman los expertos, la mayoría de los laboratorios no cuentan con congruencia visual en sus perfiles y se enfocan en compartir excesiva presencia de personas que “sobre-humanizan” innecesariamente los contenidos.Para analizar este apartado de la estrategia de comunicación, desde un punto de vista cualitativo, se ha tenido en cuenta la distribución de contenidos y cómo las marcas conectan con sus audiencias, mientras responden de forma exitosa a una estrategia de posicionamiento que aporta valor al usuario. En este sentido, Astrazeneca queda fuera, y Abbvie y Boehringer son los ganadores. 

Diana Ramos Agosto 2023

En general, en este sentido, el sector escoge contenidos con un peso corporativo muy marcado, pero tienen que tener cuidado y no olvidarse del usuario y sus necesidades. Es importante ser relevante para construir autoridad de marca y esto se consigue aportando valor a través de contenidos que pongan en escenario a los usuarios.

El informe concluye que, en este punto, es importante recordar que las redes sociales son espacios para construir comunidad y por esta razón, “debemos entender que nuestro rol siempre debe ser responder y fomentar conversaciones. De esta forma, nos seguirán no sólo por nuestro aporte de valor, sino porque los hacemos sentir escuchados”.

AZ deja China?

 

AstraZeneca podría abandonar China. La farmacéutica de origen británico baraja la posibilidad de escindir su negocio en el país asiático, según recoge Financial Times, que señala que el gigante farma podría sacar la filial a cotizar en la Bolsa de Hong Kong.

Una posible escisión del negocio de AstraZeneca en China podría proteger a la farmacéutica de las tensiones del país asiático con otras potencias mundiales, de acuerdo con la información aportada por el rotativo, que añade que no es la primera vez que la multinacional sondea llevar a cabo esta acción.

Por parte de AstraZeneca declinan hacer comentarios sobre “rumores o especulaciones sobre estrategias futras o fusiones y adquisiciones”. En todo caso, la empresa es el mayor fabricante de medicamentos de China y el año pasado las ventas de la multinacional en el gigante asiático representaron el 13% de los ingresos totales, es decir, más de 5.700 millones de dólares.

AstraZeneca cerró el ejercicio económico 2022 con un beneficio de 3.293 millones de dólares, frente a los 115 millones de dólares alcanzados en 2021.La empresa justifica este crecimiento por el impulso en el negocio de sus tratamientos contra el cáncer y los efectos derivados de la integración de la biotecnológica Alexion, compañía adquirida por más de 30.000 millones de dólares.

La facturación de AstraZeneca en 2022 fue de 44.531 millones de dólares, frente a los 37.417 millones de dólares alcanzados en 2021, por lo que la multinacional mejoró sus ingresos casi un 19% en el último año.

Por actividad, el área de oncología reportó unos ingresos de 14.631 millones de dólares a AstraZeneca en 2022, un 13% más en comparación con los resultados de 2021. El producto estrella en este segmento es Tagrisso, tratamiento en primera línea para el cáncer de pulmón no microcítico, que obtuvo ventas de 5.444 millones de dólares en 2022.

El área de enfermedades raras ingresó 7.053 millones de dólares en 2022, cifra un 4% superior a la de 2021. El negocio de otras medicinas, sin embargo, facturó un 5% menos, hasta 1.625 millones de dólares 

USA: AstraZeneca abandona PhRMA

British drugmaker AstraZeneca (NASDAQ:AZN) has decided to leave the Pharmaceutical Research and Manufacturers of America (PhRMA), the major pharmaceutical lobby group in the U.S., the company said.

The influential industry trade group counts pharma giants such as Pfizer (PFE), Amgen (AMGN), Bristol Myers (BMY), J&J (JNJ), and Merck (MRK) as some of its members.

AstraZeneca (AZN) has decided not to renew its membership at PhRMA following a review to evaluate whether it was "the most productive and effective use of (company) resources," Reuters reported quoting a spokesperson for the company.

The statement further indicated that in the wake of the exit, AstraZeneca (AZN) plans to reallocate the funds previously spent on PhRMA membership to pursue U.S. advocacy efforts with state and federal policymakers.

The move first reported by Politico comes amid pressure on drugmakers following the implementation of the Biden administration's recent drug pricing reforms.

Pharma giants AbbVie (ABBV) and Teva Pharmaceutical (TEVA) announced their departure from PhRMA early this year.

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Fármacos protagonistas 2023...

 

FDA: AstraZeneca and Avillion’s* Airsupra a “paradigm shift” for asthma care

 

The Food and Drug Administration approved AstraZeneca and Avillion’s* Airsupra (formerly PT027), as an asthma rescue treatment .

The approval came after the results of the drug’s MANDALA and DENALI Phase III trials, which found that Airsupra “significantly reduced the risk of severe exacerbations” when used as an as-needed rescue medication compared to albuterol in patients with moderate-to-severe asthma.

From a clinical perspective, Airsupra met its secondary endpoint of mean annualized total systemic corticosteroid exposure by demonstrating a significant reduction compared to albuterol at a dosage of 180mcg albuterol/160mcg budesonide.

Meanwhile, in the DENALI trial, the treatment “significantly improved lung function” in patients with mild-to-moderate asthma compared to just albuterol and budesonide.  

Airsupra, a pressurized metered-dose inhaler, is now approved as a treatment for adults with asthma in the U.S.

The Airsupra news is a major development for the approximately 25 million people in the U.S. who have asthma, according to the Asthma and Allergy Foundation of America, 20 million of whom are over the age of 18.

The FDA approval of Airsupra also represents a “paradigm shift” for asthma care and can “revolutionize” treatment options for patients, according to Elizabeth Bodin, VP of U.S. respiratory and immunology at AstraZeneca.

Bodin said the upshot of the decision is that AstraZeneca wants to replace short-acting beta-agonists (SABAs) as the standard of care for asthma with Airsupra. She noted that in the past, the U.S. has lagged behind in adopting guidelines for anti-inflammatory rescue treatment.

“From a marketing perspective, we have an important opportunity to educate about the underlying role that inflammation plays in asthma,” she said. “The role we have to play in education is that inflammation is a distinctive feature of asthma and it plays a key role in both the asthma symptoms and the exacerbations. We need to leverage our marketing vehicles to bring that and more to the forefront of asthma rescue therapy.”

Bodin added that AstraZeneca now has the opportunity to extend its leadership in asthma care as well as further its commitment to treating respiratory diseases and grow its immunology portfolio. She said that the company expects to triple its business in respiratory, based on the current portfolio and pipeline.

AstraZeneca has been a longtime player in the asthma space, most recently launching their Asthma Behaving Badly effort in September. The campaign features Phil, a purple, anthropomorphic representation of an eosinophil to help raise awareness of a common but serious and often overlooked form of asthma.

 Meanwhile, as some companies have pulled back on their efforts in the asthma space, others have doubled down.

In October, Sanofi and Regeneron teamed up with Broadway actor and reality TV star Tommy Bracco to promote the launch of JoinLungZone.com. The website encourages patients living with uncontrolled moderate-to-severe asthma to ask their doctor about treatment involving Dupixent.

AstraZeneca has plans to lean into its marketing capabilities to promote Airsupra as a critical treatment option for patients and providers in the months to come.

“It’s an energizing space for any marketer to operate in because when you take something where you need to cause a paradigm shift and couple it with an area of high unmet need that has a big impact on patients, that’s consistent with what we’re trying to do strategically as an organization to transform care for patients,” she said. Más

 

*Avillion LLP, a drug development company focused on the co-development and financing of pharmaceutical candidates from proof-of-concept through to regulatory approval,

Regresando de nuevo a...Davos2023

En el ámbito empresarial, la selecta lista de invitados a Davos incluye a 60 consejeros delegados de todos los sectores y países del mundo. La plana mayor de las principales multinacionales suizas podrá presumir un desempeño mucho mejor en 2022 del que reportaron en el año previo. 

Los principales ejecutivos de ABB, Adecco, AstraZeneca, Novartis, Roche, MKS Pamp, Nestlé y SICPA; así como los gigantes bancarios suizos Credit Suisse y UBS, y la reaseguradora SwissRe han puesto a Davos en su agenda. Más

 Ver:

Novartis "habitué in Davos" en PHARMACOSERÍAS

JAMA: Financial Penalties Imposed on Large Pharmaceutical

Among 26 firms in our sample, 22 (85%) had financial penalties for illegal activities. The combined dollar value of financial penalties totaled $33 billion for 2003 to 2016. 

Eleven firms with financial penalties exceeding $1 billion in inflation-adjusted dollars accounted for $28.8 billion (88%) of the total penalties. 

The firms with the highest penalties as a percentage of revenues (ie, >1%) were Schering-Plough, GlaxoSmithKline, Allergan, and Wyeth; the number of penalties for these firms varied between 1 (Allergan) and 27 (GlaxoSmithKline). 

Four firms had financial penalties that totaled less than $80 million and no more than 2 penalty settlements (Actavis [Watson], Roche Group, Genzyme, and Perrigo). All but 1 firm (Perrigo) engaged in illegal activities associated with penalties for 4 or more years. 

An additional 4 firms received no financial penalties for illegal activities during this period. The most common types of illegal activity involving penalties were 

• pricing violations, 
• off-label marketing, and 
• kickbacks. 

The firms with the greatest variety in the types of illegal activities involving penalties were GlaxoSmithKline, Bristol Myers Squibb, and Merck. 

Three firms (Actavis, Allergan, and Perrigo) had penalties limited to a single violation type.

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MRS: "Top ten " Reputación sanitaria

 

Pfizer, Novartis y Janssen siguen siendo, por segundo año consecutivo, las empresas farmacéuticas con mejor reputación en España, según refleja el Monitor de Reputación Sanitaria (MRS). En esta octava edición, completan el 'top ten' Astrazeneca (4º), GSK (5º), Lilly (6º), Roche (7º), Bayer (8º), AbbVie (9º) y Sanofi (10º).

 Por áreas terapéuticas, en Alergología la compañía con mejor reputación es Novartis; en Anestesiología y Reanimación, MSD; en Aparato Digestivo, Abbvie; en Cardiología, Novartis; en Cirugía General y Aparato Digestivo, Pfizer; en Cirugía ortopédica y Traumatología, Pfizer; en Dermatología médicoquirúrgica y venerología, Janssen; en Endocrinología y nutrición, Novo Nordisk; y en Hematología, Janssen.

Pfizer es según el MRS la farmacéutica más reputada en Medicina Familiar y Comunitaria, Medicina Intensiva, Medicina Interna; mientras que AstraZeneca en Nefrología; GSK en Neumología, Otorrinolaringología y Pediatría; Novartis en Neurología y Oftalmología; Gedeon Richter en Obstetricia y Ginecología; Roche en Oncología Médica; Janssen en Psiquiatría; Abbvie en Reumatología; y Astellas Pharma en Urología.

En el área de empresas con mejor reputación y más innovadoras por áreas terapéuticas; las mejores empresas de tecnología sanitaria, que encabezan Siemens (1º), Philips (2º) y General Electric (3º); y el ranking de los fabricantes de dispositivos biomédicos con mejor reputación, liderado por KLS Martin (1º), Depuy Synthes (2º) y Stryker (3ºç

Como novedad, en esta edición, se han presentado a los líderes empresariales del sector farmacéutico con mejor reputación. Un ranking que encabeza Jesús Ponce (Novartis), seguido de Sergio Rodríguez (Pfizer), Juan López-Belmonte Encina (Laboratorios Rovi), Luis Díaz-Rubio (Janssen), Ana Argelich (MSD), Nabil Daoud (Lilly), Margarita López Acosta (Sanofi), Cristina Henríquez de Luna (GSK), José María Fernández Sousa-Faro (Pharmamar) y Stefanos Tsamousis (Roche).

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Creatividad: El cáncer no espera / AstraZéneca