domingo, 23 de enero de 2022

No time to die: An in-depth analysis of James Bond's exposure to infectious agents / Travel Medicine:

 


Global travelers, whether tourists or secret agents, are exposed to a smörgåsbord of infectious agents. We hypothesized that agents pre-occupied with espionage and counterterrorism may, at their peril, fail to correctly prioritize travel medicine. 

To examine our hypothesis, we examined adherence to international travel advice during the 86 international journeys that James Bond was observed to undertake in feature films spanning 1962–2021. Scrutinizing these missions involved ∼3113 min of evening hours per author that could easily have been spent on more pressing societal issues. 


James Bond's exposure to infectious diseases and other relevant travel-associated risks. 

Depicted are travel related health threats experienced by James Bond during 86 international journeys involving 47 geographically identifiable countries. 

Health risks are presented in frequency of total observations in the following categories: 

  • Food safety (dark green), 
  • Air and droplet borne viruses (yellow), 
  • Vector borne & Neglected tropical diseases (brown), 
  • Health and safety (purple), 
  • Sexual health (blue), 
  • Exposure to animals (red), and 
  • Diseases (light green).


We uncovered above-average sexual activity, often without sufficient time for an exchange of sexual history, with a remarkably high mortality among Bond's sexual partners (27.1; 95% confidence interval 16.4–40.3). Given how inopportune a bout of diarrhea would be in the midst of world-saving action, it is striking that Bond is seen washing his hands on only two occasions, despite numerous exposures to foodborne pathogens. 

We hypothesize that his foolhardy courage, sometimes purposefully eliciting life-threatening situations, might even be a consequence of Toxoplasmosis. 

Bond's approach to vector-borne diseases and neglected tropical diseases is erratic, sometimes following travel advice to the letter, but more often dwelling on the side of complete ignorance. 

Given the limited time Bond receives to prepare for missions, we urgently ask his employer MI6 to take its responsibility seriously. 

We only live once.

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sábado, 22 de enero de 2022

Se acabó el Diazepam...Leiva & Natalia Lafourcade


 

Cuando despierto y el agua me cubre hasta la mitad

Me vuelvo a dormir

Y descubro que sigo abrazado a la nada

Tengo un instante de calma y un billete a la capital

Te podrías apuntar

Me he quedado pensando a los pies de la cama

Si me observaras por un agujerito, te darías la vuelta

Pero eso nunca pasa

Me imaginas abriendo las alas

Mareando detrás de los brazos de alguna cualquiera

Yo había venido a salvarte

Tú no necesitas que nadie te salve

Ya no había nadie al volante

Solo necesito un plan

Y aullar, aullar toda la noche

Aullar, aullar toda la noche

Hasta que me quede sin voz

Voy galopando, por dentro, a toda velocidad


Se acabó el Diazepam

Y he pedido por Glovo Peaky Blinders entera

Si me miraras por un agujerito, morirías de pena

Pero eso nunca pasa

Me imaginas abriendo las alas

Mareando detrás de los brazos de alguna cualquiera

Yo había venido a salvarte

Tú no necesitas que nadie te salve

Ya no había nadie al volante

Solo necesito un plan

Y aullar, aullar toda la noche

Aullar, aullar toda la noche

Aullar, aullar toda la noche

Hasta que me quede sin voz

Hasta que me quede sin voz, sin voz

 


 

viernes, 21 de enero de 2022

Cinema Paradiso: 4 dias / Rodrigo García

 

La adicción a las drogas es un problema de salud, no criminal” 

Rodrigo García

"4 días" se inspira en un reportaje escrito por el ganador del Pulitzer Eli Saslow titulado How’s Amanda? y publicado por The Washington Post en el que se cuenta la historia de una joven de Detroit que acabó siendo adicta a los opiáceos. 

Durante una década, la bella Amanda (Mila Kunis), acabó habitando los peores “lugares físicos” en una caída sin freno. Cuando quiere rehabilitarse, por enésima vez, su madre (Glenn Close), teme que sus buenas intenciones vuelvan a jugar en su contra. Al final, decide darle una oportunidad aunque no se quita el miedo de encima a que la robe o le tome el pelo. Comienza una “renegociación de la relación” en la que el amor de la madre será capaz de sanar a una hija enferma, que no criminal, en una película que tiene como telón de fondo la grave crisis de opiáceos que atraviesa Estados Unidos y provocó cincuenta mil muertos en 2019.

...

El problema de las drogas es mundial y súper complejo. En el caso de esta pandemia de opiáceos en Estados Unidos empezó hace quince o veinte años. Sin duda gran parte de la culpa la tienen las compañías farmacéuticas, no solo produciendo estas pastillas a granel, también dándoles a los médicos incentivos muy claros para que dieran la mayor cantidad de recetas posibles. Se creó una cadena de lucro, de ganancias, de las farmacéuticos, los médicos, los distribuidores, las farmacias… Una sola farmacia en West Virginia leí que en un año facturaron un millón y medio de euros solo con estos medicamentos. Saturaron el mercado y al final se supo todo, ha estallado y hay enormes demandas billonarias que han tenido que pagar las farmacéuticas. Ahora hay más controles pero hicieron un daño tremendo. Creo que en la película se hace referencia a eso cuando por ejemplo la madre dice que “todo esto es culpa de los médicos”, pero lo importante para mí es como lo llevan la madre y la hija. 

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jueves, 20 de enero de 2022

VIAGRA (sildenafil) as candidate drug for Alzheimer’s disease


 

According to findings published in Nature Aging, the research team, led by Feixiong Cheng, Ph.D., of Cleveland Clinic's Genomic Medicine Institute, used computational methodology to screen and validate FDA-approved drugs as potential therapies for Alzheimer's disease. Through a large-scale analysis of a database of more than 7 million patients, they determined that sildenafil is associated with 69% reduced incidence of Alzheimer's disease, indicating the need for follow-up clinical trial testing of the drug's efficacy in patients with the disease.


"Recent studies show that the interplay between amyloid and tau is a greater contributor to Alzheimer's than either by itself," said Dr. Cheng. "Therefore, we hypothesized that drugs targeting the molecular network intersection of amyloid and tau endophenotypes should have the greatest potential for success."

Without the development of effective new treatments, Alzheimer's disease is set to impact 13.8 million Americans by 2050, underscoring the need for rapid development of prevention and treatment strategies. Drug repurposing -- use of an existing drug for new therapeutic purposes -- offers a practical alternative to the costly and time-consuming traditional drug discovery process. 

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miércoles, 19 de enero de 2022

Turing Pharmaceuticals: ‘Pharma Bro’ Martin Shkreli fined $64M, banned from drug industry

 


Convicted “Pharma BroMartin Shkreli has been ordered to return $64 million in profits his company made by inflating the price of a life-saving drug, a federal judge in New York ruled on Friday.

Shkreli, who is currently serving a seven-year prison sentence for securities fraud after he was convicted in 2017, is also barred from ever working in the pharmaceutical industry again.

Ver:

Todo sobre  Shkreli, Daraprim y Turing Pharmaceuticals en PHARMACOSERÍAS


US District Judge Denise Cote handed down the ruling on Friday, ending a weeks-long civil lawsuit brought against Shkreli by the Federal Trade Commission and seven states.

Shkreli, who is currently behind bars at a low-security federal prison in Allenwood, Pennsylvania, became one of the most-hated executives in America.

In 2015, Shkreli’s company, Turing Pharmaceuticals, acquired the rights to Daraprim, a life-saving drug that is used to treat infections that occur in patients suffering from cancer and AIDS.

Turing, which is now known as Vyera, then raised the price of the drug from $13.50 per pill to $750 per pill.

According to court papers, Shkreli said at the time that the move “should be a very handsome investment for all of us.”

He defended the decision as capitalism at work and said insurance and other programs ensure that people who need Daraprim would ultimately get it.

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