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44 instances of the primary outcome were classified as ‘provoked‘ because they were associated with cancer or recent trauma, hospital admission or surgery. The risk reduction was similar in both the ‘provoked’ and ‘unprovoked’ subgroups. There was a increased tendency to pulmonary embolism in the rosuvastatin group but this was not statistically significant.

Although these findings are interesting, further research is required to quantify potential benefits in patients at higher risk of venous thromboembolism. In addition, hs-CRP tests are currently not widely available and the clinical significance of hs-CRP results lacks consensus.

Statins should not be routinely used with the exclusive aim of preventing VTE. Efficacy and safety has not been demonstrated in individuals at high risk

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