jueves, 7 de enero de 2010

Antidepresivos...solo en casos severos.

WASHINGTON -(Dow Jones)- Patients with severe depression receive the most benefit from treatment with antidepressant medications while those with less severe symptoms see little or no benefit, according to a new analysis released Tuesday.

A group of researchers combined the results of six studies involving patients who ranged from mildly depressed to very severely depressed as rated on the Hamilton Depression Rating Scale, which doctors use to determine if a person is depressed. The analysis, which compared 718 patients assigned to an antidepressant or a placebo is published in this week's Journal of the American Medical Association. (Ver...)


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2 comentarios:

  1. Enrique Gavilán7 de enero de 2010, 18:31

    Las conclusiones vienen a corroborar lo que ya demostró el rompedor metanálisis publicado en PloS Med (PLoS Med 5(2): e45. doi:10.1371/journal.pmed.0050045) hace casi dos años:

    Drug–placebo differences in antidepressant efficacy increase as a function of baseline
    severity, but are relatively small even for severely depressed patients. The relationship between
    initial severity and antidepressant efficacy is attributable to decreased responsiveness to
    placebo among very severely depressed patients, rather than to increased responsiveness to
    medication.

    Ahora toca sacar conclusiones para la práctica, y buscar alternativas a la medicación para el tratamiento de las depresiones moderadas...
    Gracias, Fernando

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  2. pharmacoserias7 de enero de 2010, 19:44

    Gracias Enrique por tú comentario.
    Este tema de los antidepresivos dá y dará mucho que hablar. A mi, en este "post" se me olvidó referenciar a otro anterior

    http://pharmacoserias.blogspot.com/2008/11/zoloft-prozac-paxil-todos-son-iguales.html

    y que voy a añadir.
    Todo lo mejor para 2010.

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